Aetolia-Acarnania is one of the regional units of Greece. It is part of the geographic region of Central Greece.
it is the country's largest regional unit. Its capital is Messolonghi for historical reasons, with its biggest city and economic centre at Agrinio.The area is now connected with the Peloponnese peninsula via the Rio-Antirio Bridge.
Mountains dominate the north, northeast, west and southeast, especially the Acarnanian Mountains. The longest and main river is the Acheloos, which ends as a delta in wetlands to the southwest on a rich fertile valley. The second longest is Evinos; others include the Ermitsa, the Inachos, and the Mornos (on the border with Phocis). Lakes include the Amvrakia, the Lysimachia, Ozeros, and Trichonida, and artificial lakes and reservoirs include Kastraki, Kremasta, the largest lake in Greece since its creation in 1970, and Stratos. Two lagoons are found in the southern part of the regional unit: the Messolongi and the Aitoliko.The lowest altitude in Greece is found in west Aetolia-Acarnania at about -10 meters from the sea level
The Messolonghi-Etoliko lagoon is the largest in Greece and one of the largest in the Mediterranean.
The lagoon of Messolonghi is classified as Environmental Park and is protected by the Ramsar Treaty and it is also included in the Natura 2000 network.